Mygrium® is a dietary supplement with a combination of active ingredients that contributes to the protection of cells from oxidative stress and to the normal functioning of the nervous system. In addition, it contributes to the normal synthesis and metabolism of steroid hormones, vitamin D and some neurotransmitters.

It contains an optimal and studied combination of olive polyphenols and flavonoids, carefully selected that, according to an extensive bibliography, exert an antioxidant and anti-inflammatory activity.

One theory about the cause of migraine is that it is a disorder of the central nervous system (CNS). In migraine, several stimuli can cause a series of neurological and biochemical events that affect the vascular system of the brain. It is called neurogenic inflammation, a process that also has impact on many other disorders.

Migraine consists of a multifactorial disorder with a large number of involved mechanisms in which oxidation and inflammation are fundamental.

Mygrium® incorporates vitamin C which, according to the European Food Safety Authority (EFSA), contributes to the protection of cells from oxidative stress and to the normal functioning of the nervous system.

It also includes vitamin B cofactors, which intervene in the metabolism of carbohydrates, lipids and proteins and in hundreds or thousands of enzymatic reactions essential for life that reduce speed in certain unbalanced situations.

This is the reason why its presence in Mygrium® is very important, within this objective of favoring cellular homeostasis.

These B vitamins are more effective if they are together and work synergistically.

Thiamine (B1), riboflavin (B2), niacin (B3) and pyridoxine (B6) contribute to the normal functioning of the nervous system. Riboflavin (B2) also contributes to the protection of cells from oxidative stress.

Pantothenic acid (B5) contributes to the normal synthesis and metabolism of steroid hormones, vitamin D and some neurotransmitters.

Vitamins B3 and B6 participate in the biochemical regulation of hundreds of alterations or disorders and in a greater number of reactions than the rest of the vitamins in that group.

The lack of vitamin B1 (thiamine) has been shown to reduce the metabolism of serotonin in the central nervous system, a very important mechanism in migraine.

As for vitamin B2 (riboflavin), it has been the most researched in migraine and its symptoms (“High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care center”; Boehnke et al. European Journal of Neurology, 2004).

The interictal reduction of the phosphorylation potential in the brain and muscles of migraineurs by riboflavin has been demonstrated previously (“Abnormal brain and muscle energy metabolism shown by 31P magnetic resonance spectroscopy in patients affected by migraine with aura”; Barbiroli B. et al. Al.; Neurology; 1992).

There is evidence that riboflavin (vitamin B2) reduces the frequency of migraine attacks (“Supplementation with Riboflavin (Vitamin B2) for Migraine Prophylaxis in Adults and Children: A Review”; Namazi N et al., Int J Vitam Nutr Res 2015).

Riboflavin is involved in the transfer of electrons in oxidation-reduction reactions. Patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke episodes also show reduced metabolism in the mitochondria and experience migraine-like headaches, which have been alleviated by riboflavin (“NADH-CoQ reductase deficient myopathy: successful treatment with riboflavin”; W.F. M. Arts; The Lancet, vol.2, 1983).

Schoenen et al. (1998) investigated the use of riboflavin among patients with migraine based on the hypothesis that an altered oxygen metabolism may contribute to the development of migraine attacks.

The study reported that approximately 59% of migraine patients showed at least 50% reduction in symptoms. It was also concluded that riboflavin is a good option for the prophylaxis of migraine due to its high efficacy and excellent tolerability.

In U.S.A. a randomized, placebo-controlled study (48) in both groups of patients receiving low or high doses of riboflavin had a significant reduction in the number of migraine attacks and in the number of days with migraine (Maizels M. et al, 2004).

Another study suggested that riboflavin may be effective in the treatment of migraine (M. Condó et al., 2009). The study reported that 68.4% of patients with migraine had a reduction of 50% or more in the frequency of migraine attacks and 21% in their intensity.

Boehnke et al. (2004) demonstrated the efficacy of riboflavin in patients with migraine. The study also reported a reduction (? <0.05) in headache frequency from 4 days/month at baseline to only 2 days/month after riboflavin use, but there were no changes in the duration or intensity of the headache experienced.

“Riboflavin has neuroprotective potential: focus on Parkinson’s Disease and Migraine”; Marashly ET; Front Neurol. 2017: “In conclusion, riboflavin is a potential neuroprotective agent that affects a wide range of neurological disorders exemplified by PD, a disorder of neurodegeneration and migraine headache, a pain disorder”.

Also a relationship between co-enzyme Q10 and riboflavin (Markley HG, “Coenzyme Q10 and riboflavin: The mitochondrial connection”; Headache, 2012).

Vitamin B3 (niacin) also has participation in the formation of serotonin.

Vitamin B6 (pyridoxine) is also relevant for the normal synthesis of cysteine. Cysteine ​​is part of glutathione, essential for the glutathione peroxidase (GPX) enzyme to develop its activity.