The biophenols present in Mygrium^® are part of our diet through the consumption of olives and virgin olive oil.

Polyphenols such as hydroxytyrosol have been shown to increase endogenous glutathione levels (“Olive Phenolics increase glutathione levels in healthy volunteers”; Visioli et al., J. Food Agric Chem. 2009). Glutathione is a key component in our body capable of preventing the damage that occurs at the cellular level caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides and heavy metals.

The European Food Safety Authority (EFSA) recommends the daily consumption of olive polyphenols for the general population and the European Commission approved a health claim under the EC standard 1924/2006, declaring that “olive polyphenols contribute to the protection of blood lipids from oxidative stress”.

Studies made on extra virgin olive oil, olive polyphenols and their anti-inflammatory activity:

• ☻ “Phenolic compounds extracted from olive oil prevent oxidation of low density lipoproteins and inhibit platelet function and platelet and leukocytes eicosanoid production in vitro. In Oxidative Processes and Antioxidants, Paoletti R, Samuelsson B, Catapano AL, Poli A, Rinetti M (eds). Raven Press: New York, 199–206 (1994)
• ☻ Petroni, A., Blasevich, M., Salami, M., Servili, M., Montedoro, G. F. & Galli, C. (1994) A phenolic antioxidant extracted from olive oil inhibits platelet aggregation and arachidonic acid metabolism in vitro. World Rev. Nutr. Diet. 75: 169–172.
• ☻ Petroni A, Blasevich M, Salami M, Papini N, Montedoro GF, Galli C.Inhibition of platelet-aggregation and eicosanoid production by phenolic components of olive oil. Thromb Res 1995;78:151– 60.
• ☻ Petroni A, Blasevich M, Papini N, Salami M, Sala A, Galli C. Inhibition of leukocyte leukotriene B-4 production by an olive oil-derived phenol identified by mass-spectrometry. Thromb Res 1997;87:315–22.
• ☻ de la Puerta R, Gutierrez VR, Hoult JRS. Inhibition of leukocyte 5-lipoxygenase by phenolics from virgin olive oil. Biochem Pharmacol 1999;57:445–9.
• ☻ de la Puerta R, Martinez-Dominguez E, Ruiz-Gutierrez V. Effect of minor components of virgin olive oil on topical anti-inflammatory assays. Z Naturforsch C 2000;55:814-9. [110 98836]
• ☻ Martínez-Domínguez E, de la Puerta R, Ruiz-Gutiérrez V (2001) Protective effects upon experimental inflammation models of a polyphenol-supplemented virgin olive oil diet. Inflamm Res 50:102–106
• ☻ Tuck KL, Hayball PJ. Major phenolic compounds in olive oil: metabolism and health effects. J Nutr Biochem 2002;13:636–44.
• ☻ Carluccio MA, Siculella L, Ancora MA, Massaro M, Scoditti E, Storelli C, et al. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation—antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol 2003;23:622–9.
• ☻ Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood cultures Elizabeth A. Miles, Ph.D et al. 2004
• ☻ Maria Chiara Maiuri, Daniela De Stefano, Paola Di Meglio, Carlo Irace, Maria Savarese,
• ☻ Raffaele Sacchi, Maria Pia Cinelli, Rosa Carnuccio: Hydroxytyrosol, a phenolic compound from virgin olive oil, prevents macrophage activation (2005)
• ☻ Beauchamp GK, Keast RS, Morel D, Lin J, Pika J, Han Q, et al. Phytochemistry:
• ☻ ibuprofen-like activity in extra-virgin olive oil. Nature 2005;437(7055):45–6.
• ☻ Maiuri MC, De Stefano D, Di Meglio P, Irace C, Savarese M, Sacchi R, et al.
• ☻ Hydroxytyrosol, a phenolic compound from virgin olive oil, prevents macrophage activation. Naunyn Schmiedebergs Arch Pharmacol 2005;371(6):457–65.
• ☻ Miles EA, Zoubouli P, and Calder PC (2005) Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood cultures. Nutrition 21:389–394.
• ☻ Bitler et al. Hydrolyzed Olive Vegetation Water in Mice Has Anti-Inflammatory Activity (2005)
• ☻ Puel C, Mathey J, Agalias A, Kati-Coulibaly S, Mardon J, Obled C, Davicco MJ, Lebecque P, Horcajada MN, Skaltsounis AL, Coxam V. Dose-response study of effect of oleuropein, an olive oil polyphenol, in an ovariectomy/inflammation experimental model of bone loss in the rat. Clin Nutr 2006;25:859-68. [1674 0345] [doi.org/10.1016/j.clnu.2006. 03.009]
• ☻ Corona G, Deiana M, Incani A, Vauzour D, Dessì MA, Spencer JP. Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects. Biochem Biophys Res Commun 2007;362(3):606–11.
• ☻ Bogani P, Galli C, Villa M, Visioli F. Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil. Atherosclerosis 2007;190(1):181–6.
• ☻ Fitó M, Cladellas M, de la Torre R, Martí J, Muñoz D, Schröder H, et al. SOLOS
• ☻ Investigators. Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial. Eur J Clin Nutr 2008;62(4):570–4.
• ☻ Zhang X, Cao J, Zhong L. Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells. Naunyn Schmiedebergs Arch Pharmacol 2009;379(6):581–6.
• ☻ Effects of Hydroxytyrosol-20 on Carrageenan induced Acute Inflammation and Hyperalgesia in Rats Dezheng Gong et al. 2009
• ☻ Lucas L, Russell A, Keast R. Molecular mechanisms of inflammation. Anti-inflammatory benefits of virgin olive oil and the phenolic compound oleocanthal. Curr Pharm Des 2011;17(8):754–68.
• ☻ Sánchez-Fidalgo S, Sánchez de Ibargüen L, Cárdeno A, Alarcón de la Lastra C. Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model. Eur J Nutr 2011;51:497–506.
• ☻ Patrizia Rosignoli et al. Effect of olive oil phenols on the production of inflammatory mediators in freshly isolated human monocytes (2012)
• ☻ Khalatbary et al  Anti-Inflammatory Effect of Oleuropein in Experimental Rat Spinal Cord Trauma (2012)
• ☻ Ana Cardeno et al. Unsaponifiable fraction from extra virgin olive oil inhibits the inflammatory response in LPS-activated murine macrophages (2013)